Articles Vol. 65 No. CĐ 3 - Bệnh viện Phổi Trung ương 15/05/2024

34. CHARACTERISTICS OF EGFR MUTATIONS IN PATIENTS WITH ADENOCARCINOMA LUNG CANCER UNDERGOING SURGERY AT NATIONAL LUNG HOSPITAL IN 2022

Nguyen Si Khanh1,2, Nguyen Huy Binh1,2, Dang Duy Duc1,2, Nguyen Duc Tuyen1,2, Vu Quy Duong1,2, Le Xuan Hieu1,2, Dinh Van Luong1,2
1 National Lung Hospital
2 Bệnh viện Phổi Trung ương
Corresponding author: Dangduyduc225@gmail.com
DOI: 10.52163/yhc.v65iCD3.1131
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Keywords
Non-small cell lung cancer, EGFR gene mutation
Abstract

Background: Lung cancer is increasingly being detected early, and surgical treatment has a very high survival rate of over 5 years. However, there are still some recurrences after surgery, leading to changes in treatment strategies before and after surgery. In addition to chemotherapy, there are also immunotherapy methods and tyrosine kinase inhibitors. In particular, EGFR mutation testing plays an important role in providing treatment strategies before and after surgery.

Objective: Evaluate gene mutation testing in adenocarcinoma lung cancer patients treated surgically at the National Lung Hospital.

Subjects and methods: Lung cancer patients diagnosed by histopathology. In which, EGFR gene mutations were determined using Viennalab's Strip Assay method from biopsy or surgical specimens at the Department of Pathology of the National Lung Hospital.

Results: 40 patients were tested for EGFR gene mutations. Among them, 24/40 patients were EGFR positive. 9 patients are positive on Exon 19, 15 patients are positive on Exon 21

Conclusion: From the above results, it shows that EGFR mutation testing in lung cancer patients and the possibility of surgery is a factor in assessing prognosis and providing treatment possibilities before and after surgery.

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