Congenital Cyst Adenomatoid Malformation (CCAM), also known as Congenital Pulmonary Airway Malformation (CPAM), is an abnormality of lung tissue, containing many small cysts concentrated in clusters in the lung lobes, originating mainly from the bronchioles. About 70% are detected within the first week of life, 10% are diagnosed after 1 year, and reported cases in adults are very rare. CCAM can develop in any lobe of the lung, but most occur in the lower lobe. CCAM are connected to the bronchial tree and are supplied by the pulmonary artery; the absence of a feeding artery is rarely seen. Typical CCAM is divided into 3 main types (I – III) based on differences in histology, pathological manifestations, radiological manifestations and prognosis. Two additional types of CCAM have also been proposed, that are 0 type and IV type, based on the medical history found and the type of epithelial cells seen in the airways present in the abnormality. The term CPAM is proposed to include these types of extensions. We report 1 cases of CCAM, diagnosed by postoperative pathology. We will also update related documents about this abnormality in the article with the hope of providing colleagues with an overview and approaches to diagnosis and treatment when encountering similar cases.
32. CONGENITAL CYST ADENOMATOID MALFORMATION: A LITERATURE REVIEW AND CASE REPORT
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Congenital adenoid cystic abnormalities, pulmonary adenoid cysts, pulmonary cystic abnormalities, multiple pulmonary cysts.
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References
[1]
W. Richard Webb; Charles B, Higgins. Thoracic
Google Scholar
[2]
Imaging: Pulmonary and Cardiovascular Radiology.
Google Scholar
[3]
Third Edition; p. 208 -275.
Google Scholar
[4]
Morelli L, Piscioli I, Licci S et al., Pulmonary
Google Scholar
[5]
congenital cystic adenomatoid malformation,
Google Scholar
[6]
type I, presenting as a single cyst of the middle lobe
Google Scholar
[7]
in an adult: Case report. Diagn Pathol.
Google Scholar
[8]
Jun 7;2:17. doi: 10.1186/1746-1596-2-17.
Google Scholar
[9]
PMID: 17555585
Google Scholar
[10]
Morotti RA, Cangiarella J, Gutierrez MC et al.,
Google Scholar
[11]
Congenital cystic adenomatoid malformation
Google Scholar
[12]
of the lung (CCAM): Evaluation of the cellular
Google Scholar
[13]
components. Hum Pathol. 1999 Jun;30(6):618-
Google Scholar
[14]
doi: 10.1016/s0046-8177(99)90084-9.
Google Scholar
[15]
PMID: 10374767
Google Scholar
[16]
Badour M, Hussain B, Hammed A et al., A rare
Google Scholar
[17]
case of congenital cystic adenomatoid malformation:
Google Scholar
[18]
Mimics pneumonia manifestations. Ann
Google Scholar
[19]
Med Surg (Lond). 2021 May 27;66:102433. doi:
Google Scholar
[20]
1016/j.amsu.2021.102433. eCollection 2021
Google Scholar
[21]
Jun.PMID: 34136211
Google Scholar
[22]
Nagasaka S, Kina S, Arimoto Y et al., Rare localized
Google Scholar
[23]
extralobar sequestration with congenital
Google Scholar
[24]
cystic adenomatoid malformation: A case report.
Google Scholar
[25]
Surg Case Rep. 2017 Dec;3(1):47. doi: 10.1186/
Google Scholar
[26]
s40792-017-0321-3. Epub 2017 Mar 21. PMID:
Google Scholar
[27]
Muntean A, Banias LE, Ade-Ajayi N et al.,
Google Scholar
[28]
Neonatal congenital pulmonary airway malformation
Google Scholar
[29]
associated with mucinous adenocarcinoma and KRAS
Google Scholar
[30]
mutations. J Pediatr Surg.2022 Nov;57(11):520-526.
Google Scholar
[31]
doi: 10.1016/j.jpedsurg.2021.12.018. Epub 2021 Dec 25.
Google Scholar
[32]
PMID:34980466
Google Scholar
[33]
Fitzgerald DA, Congenital cyst adenomatoid
Google Scholar
[34]
malformations: Resect some and observe all?
Google Scholar
[35]
Paediatr Respir Rev. 2007 Mar;8(1):67-76. doi:
Google Scholar
[36]
1016/j.prrv.2006.10.001. Epub 2007 Feb 9.
Google Scholar
[37]
PMID: 17419980
Google Scholar
[38]
Pederiva F, Rothenberg SS, Hall N et al., Congenital
Google Scholar
[39]
lung malformations. Nat Rev Dis Primers. 2023 Nov 2;
Google Scholar
[40]
(1):60. doi: 10.1038/s41572-023-00470-1. PMID: 37919294
Google Scholar