Articles Vol. 65 No. CĐ 3 - Bệnh viện Phổi Trung ương 15/05/2024

22. MICROBIOLOGICAL AND RADIOGRAPHIC FEATURES OF PATIENTS WITH INVASIVE PULMONARY ASPERGILLOSIS INFECTION IN NATIONAL LUNG HOSPITAL

Nguyen Thi Bich Ngoc1,2, Khuat Thi Luong1,2, Mai Manh Tu1,2
1 National Lung Hospital
2 Bệnh viện Phổi Trung ương
Corresponding author: Luongkhuat.dr@gmail.com
DOI: 10.52163/yhc.v65iCD3.1118
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Keywords
Aspergilloma, invasive aspergillosis, microbiology, lung lesion.
Abstract

Objective: To describe the microbiological and radiographic features of patients with invasive pulmonary Aspergillosis treated at the National Lung Hospital.

Methods: Retrospective descriptive study on 47 patients with invasive pulmonary Aspergillosis, treated at the National Lung Hospital from January 2019 to December 2020.

Results: The average age was 54 ± 14 years old. Patients had host factors of EORTC/MSG were 63.8%, mainly hematological malignancies (34%) and long-term corticosteroid use (23.4%). Bronchoscopy features: Pseudomembrane (35.5%), necrotic nodule (21.9%), ulcer (20.6%), warty lesion, infiltration, purulent exudates were range from 10-14%. The most common lung lesions on chest CT are nodules (70.2%), consolidations (51.1%), and cavities (27.7%), multiple lesions appearing in both sides. Microbiological findings: sputum culture (50%), bronchoalveolar lavage culture (45.5%); blood galactomannan (66.7%), bronchoalveolar lavage galactomannan (40%); blood Aspergillus-specific lateral-flow device (LFD Aspergillus) (71.4%), bronchoalveolar lavage LFD Aspergillus (66.7%).

Conclusion: Invasive pulmonary Aspergillosis has been reported increasingly. Early diagnosis and treatment reduce mortality. Combining the host factors, microbiological findings, and radiographic features helps clinicians establish diagnosis.

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