Articles Vol. 65 No. 3 06/05/2024

33. STUDYING THE MEMORY ENHANCING EFFECT OF HUP A SOFT CAPSULE USING TRIMETHYLTIN CHLORIDE MODEL ON MICE

Le Thi Hong Hanh1,2, Do Minh Trung3,4, Trinh Nam Trung1,5, Nguyen Thuy Linh6,7, Nguyen Van Thu1,5
1 Pharmacy Training Institute, Military Medical University
2 iện Đào tạo Dược, Học viện Quân y
3 Military Medical and Pharmaceutical Research Institute, Military Medical University
4 Viện Nghiên cứu Y Dược học Quân sự, Học viện Quân y
5 Viện Đào tạo Dược, Học viện Quân y
6 103 Military Hospital
7 Bệnh viện Quân y 103
Corresponding author: lionqueenhvqy@gmail.com
DOI: 10.52163/yhc.v65i3.1085
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Keywords
Hup A, memory enhancement, Trimethyltin chlorid.
Abstract

Objective: Evaluating the memory enhancing effect of Hup A soft capsules using the Trimethyltin chloride (TMT) model on mice.

Method: The product used in the study is Hup A soft capsule that met Enterprise standard, mice were given Hup A at doses of 192mg/kg/24h and 384mg/kg/24h, then injected peritoneal with Trimethyltin chloride (TMT) at 2,4mg/kg/24h. Mice were tested on the Bold Hold and the Automatic Conditioned Reflex machine. Mice were monitored for the following indicators: the total number of times the mouse stuck its head into the hole within 5 minutes and the total number of times the mouse responded to avoid electric shock, and observed mouse brain histopathology.

Results: Compared to the TMT group, these Hup A groups increased the number of times these animals stuck their heads into the hole, but there was no difference (p >0.05). However, these Hup A groups increased the number of times these animals avoided electric shock and showed less damage in brain histology than the TMT group.

Conclusion: Our study showed that Hup A soft capsules enhance memory by increasing natural exploration activities, reducing anxiety, increasing the ability to avoid electric shock, and reducing brain tissue damage in mice caused by TMT.

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