Articles Vol. 65 No. 3 06/05/2024

28. EFFICACY OF POVIDONE-IODINE GLUCOSE IN THE TREATMENT OF PERFORATED ULCERS

Do Thi Thu Hien1,2,3,4, Nguyen Thi Huyen Thuong5,6, Nguyen Tran Hai Anh2,4
1 National Hospital of Dermatology and Venereology;
2 VNU University of Medicine and Pharmacy
3 Bệnh viện Da liễu Trung ương;
4 Trường Đại học Y Dược - Đại học Quốc gia Hà Nội
5 National Hospital of Dermatology and Venereology
6 Bệnh viện Da liễu Trung ương
Corresponding author: hienphuonglinh@yahoo.com
DOI: 10.52163/yhc.v65i3.1079
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Keywords
Chronic ulcer, perforated ulcer, povidone-iodine glucose, betadine.
Abstract

Objective: This study aims to compare the effectiveness of Povidone-iodine glucose (PIG) ointment and Povidone-iodine (PI) ointment in the treatment of perforated ulcers and evaluate local and systemic side effects of these two ointments.

Materials and methods: 61 patients with perforated ulcers were randomly divided into 2 groups. Group 1 comprised 32 patients treated with Povidone-iodine glucose ointment (PIG group), and group 2 comprised 29 patients treated with Povidone-iodine ointment (PI group). twice daily for 8 weeks. Treatment outcomes were assessed based on ulcer area and ulcer depth every 2 weeks. Drug side effects and patient’s satisfaction was also assessed.

Results: At week 2nd, 4th, 6th and 8th, ulcer area reduced 18.2% - 28.9% - 44.4% - 59.4% in the PIG group and 20.8% - 32.9% - 50.9% - 62.7% in the PI group, respectively. The mean reduction in ulcer depth was 0.04 – 0.1 – 0.14 – 0.2cm in PIG group and 0.08 – 0.1 – 0.18 – 0.14 cm in PI group, respectively. The difference in treatment outcomes and side effects between the 2 groups was not statistically significant. After 8 weeks of treatment, in the PIG group, patients with infected ulcers had a better reduction in lesion area than non-infected ulcers (65.9% vs. 52.6%), however, the difference was not statistically significant.

Conclusion: In the treatment of perforated ulcers, PIG ointment and PI ointment are equivalent in terms of treatment effectiveness and side effects. Although infected ulcers decreased in lesion area faster when treated with PIG ointment than with PI ointment, the difference was not statistically significant.

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