Articles Vol. 65 No. 3 06/05/2024

27. ASSOCIATION BETWEEN THE PRESENCE OF ESTROGEN RECEPTOR ON SKIN LESIONS AND SUBCLINICAL CHARACTERISTICS OF PATIENTS SYSTEMIC LUPUS ERYTHEMATOUS

Do Thi Thu Hien1,2,3,4, Le Van Trung5,6, Than Trong Tuy5,6
1 National Hospital of Dermatology and Venereology;
2 VNU University of Medicine and Pharmacy
3 Bệnh viện Da liễu Trung ương;
4 Trường Đại học Y Dược - Đại học Quốc gia Hà Nội
5 National Hospital of Dermatology and Venereology
6 Bệnh viện Da liễu Trung ương
Corresponding author: hienphuonglinh@yahoo.com
DOI: 10.52163/yhc.v65i3.1078
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Keywords
Estrogen receptor α, systemic lupus erythematosus, subclinical characteristics.
Abstract

Objective: To investigate the association between the presence of estrogen receptor α (ERα) on the skin lesions and subclinical characteristics of patients with systemic lupus erythematosus (SLE).

Subjects and methods: This is a case seriers of 65 female patients diagnosed with systemic lupus erythematosus at the National Dermatology Hospital from January 2022 to August 2023. Serum autoantibodies were examined in all 65 patients. Histopathological examination and immunohistochemical staining was conducted among 36 of 65 patients to detect the presence of ERα in the skin lesions.

Results: The positive rate of Anti Smith was 23.1%; anti Ro/SSA was 30% and anti LA/SSB was 7%. ERα was positive in 38.9% of cases and negative in 61.1% of cases. There was no association between the presence of ERα receptor on skin lesions and histopathology characteristics as well as serum autoantibodies of SLE patients.

Conclusion: The presence of ERα in skin lesions was detected in 38.9% of SLE cases. No association was found between the presence of ERα in skin lesions subclinical characteristics of SLE patients.

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