Articles Vol. 65 No. 3 06/05/2024

25. STUDY ON THE RELATIONSHIP BETWEEN SARS-COV-2 VARIANTS AND SOME SUBCLINICAL CHARACTERISTICS IN COVID-19 PATIENTS

Le Van Nam1,2, Pham Ngoc Thach3,4, Trinh Cong Dien1,2
1 Military Hospital 103
2 Bệnh viện Quân y 103
3 National Hospital for Tropical Diseases
4 Bệnh viện Bệnh nhiệt đới Trung ương
Corresponding author: levannam@vmmu.edu.vn
DOI: 10.52163/yhc.v65i3.1076
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Keywords
SARS-CoV-2 variant, COVID-19, subclinical characteristics.
Abstract

Objectives: To analyze the realtionship between the SARS-CoV-2 variants and some subclinical characteristics in COVID-19 patients.

Subjects: A descriptive, comparative, controlled study analyzing the resutls of SAR-CoV-2 genome sequencing using next generation sequencing technology.

Results: We collected 50 samples infected with Alpha, 350 samples infected with Delta and 300 samples infected with Omicron. Among the three variant groups: Ground glass and opacities were highest in the Alpha group, consolidation in the Delta group, and Opacity in the Omicron group (p < 0.05). White blood cells in the Alpha group were lower than others (p < 0.05). The ratio of neutrophils to lymphocytes (NLR) in the Alpha group was lowest (p < 0.05). AST in the Alpha group and ALT in the Delta group was higher than others (p < 0.05). Ferritin was highest in the Alpha group (p < 0.05). Meanwhile, CRP and PCT in the Delta group were highest (p < 0.05).

Conclusion: There were differences in lung lesssion between the three SARS-CoV-2 variants. The Delta group had high risk severe laboratories than the others (specially, white blood cell and inflammatory markers). The Alpha group had the highest viral load (Ct) of SARS-CoV-2.

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