Articles Vol. 65 No. CĐ 2 - NCKH 08/04/2024

42. CLINICAL MANIFESTATIONS AND RELATED FACTORS OF VITILIGO AT THE NATIONAL HOSPITAL OF DERMATOLOGY AND VENEREOLOGY IN VIETNAM FROM 2016 TO 2017

Do Thi Thu Hien1,2, Do Thi Hong Nhung3,4, Nguyen Thi Kim Tien5,6
1 National Hospital of Dermatology and Venereology
2 Bệnh viện Da liễu Trung ương
3 Hong Ngoc Hospital
4 Bệnh viện Hồng Ngọc
5 VNU University of Medicine and Pharmacy
6 Trường Đại học Y Dược - Đại học Quốc gia Hà Nội
Corresponding author: hienphuonglinh@yahoo.com
DOI: 10.52163/yhc.v65iCD2.1048
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Abstract

Objectives: Examine clinical manifestations and associated factors of vitiligo patients at the National Hospital of Dermatology and Venereology (NHDV) from 2016 to 2017.

Materials and methods: A cross-sectional descriptive study of 80 patients diagnosed with vitiligo at the NHDV from 10/2016 to 9/2017.

Results: The average age of disease onset is 26.89 ± 18.38, of which the age group of 15 to 30 years old accounted for the highest proportion (40%). The incidence rate of women was higher than that of men (56.2% vs 43.8%). The rate of comorbidities explored via asking patient’s history was 17.5%, including gastric and duodenal ulcers, atopic dermatitis and allergic diseases, and history of thyroid disease was not reported. Patients with vitiligo having skin type IV accounted for 93.7% and skin type III accounted for 6.3%. The most common location of lesions was the face and neck, accounting for 46.3%, followed by the trunk (24.3%) and the extremities (1.5%). The main clinical type was non-segmental generalised vitiligo (46.3%) while the segmental type accounted for only 2.5%. Seventy one of 80 patients were in active disease stage (with VIDA score of +1,+2,+3,+4) accounting for 88.7%, in which VIDA score of +4 accounted for the highest proportion (38.7%).

Conclusion: In our study, vitiligo was common in young people, and the disease can occur in both men and women. The disease was mainly seen in patients with skin type IV and non-segmental generalised vitiligo was the most common form. A patient can have multiple lesion locations, and the mostly involved locations were face and neck.

References
[1]
Ortone JP, Bahadoran P, Fitzpatrick TB et al., Google Scholar
[2]
Fitzpatrick’s Dermatology in general medicine. Google Scholar
[3]
McGraw-Hill Medical Publishing Division, Google Scholar
[4]
, sixth edition, 839-847. Google Scholar
[5]
C Bergqvist, K Ezzedine, Vitiligo: A Review, Google Scholar
[6]
Dermatology, 2020, 236, (6): 571–592. Google Scholar
[7]
ML Dell’Anna, M Picardo, A review and a new Google Scholar
[8]
hypothesis for non-immunological pathogenetic Google Scholar
[9]
mechanisms in vitiligo, Pigment Cell Research, Google Scholar
[10]
, 19(5): 406–411. Google Scholar
[11]
C Bergqvist, K Ezzedine, Vitiligo: A focus on Google Scholar
[12]
pathogenesis and its therapeutic implications, J Google Scholar
[13]
Dermatol, 2021, 48(3): 252–270. Google Scholar
[14]
AM Dahir, SF Thomsen, Comorbidities in Google Scholar
[15]
vitiligo: comprehensive review, Int J Dermatol, Google Scholar
[16]
, 57(10):1157–1164. Google Scholar
[17]
P Nimkar, A Wanjari, Vitiligo and the Role of Google Scholar
[18]
Newer Therapeutic Modalities, Cureus, 2022, Google Scholar
[19]
(11): e31022. Google Scholar
[20]
A Feily, Vitiligo Extent Tensity Index (VETI) Google Scholar
[21]
score: a new definition, assessment and treatment Google Scholar
[22]
evaluation criteria in vitiligo, Dermatol Pract Google Scholar
[23]
Concept, 2014, 4(4): 81–84. Google Scholar
[24]
Vũ Mạnh Hùng, Nghiên cứu đặc điểm lâm sàng Google Scholar
[25]
và một số chỉ số miễn dịch trong bệnh bạch biến, Google Scholar
[26]
Luận án Tiến sĩ, Học Viện Quân Y, 2008. Google Scholar
[27]
Phạm Thị Mai Hương, Nghiên cứu ảnh hưởng Google Scholar
[28]
của bệnh bạch biến đến chất lượng cuộc sống Google Scholar
[29]
người bệnh, Luận văn Thạc sĩ y học, Học viện Google Scholar
[30]
Quân Y, 2007. Google Scholar
[31]
VN Sehgal, G Srivastava, Vitiligo: compendium Google Scholar
[32]
of clinico-epidemiological features, Indian J Google Scholar
[33]
Dermatol Venereol Leprol, 2007, 73(3): 149– Google Scholar
[34]
AN Onunu, EP Kubeyinje, Vitiligo in the Google Scholar
[35]
Nigerian African: a study of 351 patients in Google Scholar
[36]
Benin City, Nigeria, Int J Dermatol, 2003, Google Scholar
[37]
(10): 800–802. Google Scholar
[38]
E Nicolaidou et al., Childhood- and later-onset Google Scholar
[39]
vitiligo have diverse epidemiologic and clinical Google Scholar
[40]
characteristics, J Am Acad Dermatol, 2012, Google Scholar
[41]
(6): 954–958. Google Scholar
[42]
YH Kishan Kumar, GRR Rao, KVT Gopal et al., Google Scholar
[43]
Evaluation of narrow-band UVB phototherapy Google Scholar
[44]
in 150 patients with vitiligo, Indian J Dermatol Google Scholar
[45]
Venereol Leprol, 2009, 75(2): 162–166. Google Scholar
[46]
Handa S, Dogra S, Epidemiology of childhood Google Scholar
[47]
vitiligo: a study of 625 patients from north India, Google Scholar
[48]
Pediatr. Dermatol. 2003, 20(3): 207-210. Google Scholar
[49]
J H Lee et al., Comorbidities in Patients with Google Scholar
[50]
Vitiligo: A Systematic Review and MetaAnalysis, J Invest Dermatol, 2023, 143(5): 777- Google Scholar
[51]
Vũ Mạnh Hùng, Tình hình, đặc điểm lâm sàng và Google Scholar
[52]
một số thay đổi miễn dịch trong bệnh bạch biến, Google Scholar
[53]
Luận văn Thạc sĩ y học, Học viện Quân y, 2002. Google Scholar
[54]
D Zauli et al., Prevalence of autoimmune atrophic Google Scholar
[55]
gastritis in vitiligo, Digestion, 1986, 34(3): 169- Google Scholar
[56]
F Ghalamkarpour, MC André, Y Gauthier, Google Scholar
[57]
Shared histological and immunohistological Google Scholar
[58]
findings in two patients with generalized vitiligo Google Scholar
[59]
associated with autoimmune atrophic gastritis, Google Scholar
[60]
Clin Case Rep, 2022, 10(9): e6346. Google Scholar