Articles Vol. 65 No. CĐ 2 - NCKH 08/04/2024

38. STUDYING THE MEMORY ENHANCEMENT EFFECT OF HUP A SOFT CAPSULES USING THE SCOPOLAMINE MODEL IN MICE

Le Thi Hong Hanh1,2, Do Minh Trung1,2, Trinh Nam Trung1,2, Can Van Mao1,2, Nguyen Van Thu1,2
1 Vietnam Military Medical University
2 Học viện Quân y
Corresponding author: lionqueenhvqy@gmail.com
DOI: 10.52163/yhc.v65iCD2.1043
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Keywords
Hup A, memory enhancement, scopolamine.
Abstract

Objective: Evaluating the memory enhancing effect of Hup A soft capsules using the scopolamine model.

Subject: The product used in the study is Hup A soft capsule, Enterprise standard. Methods:Mice were given Hup A at doses of 192mg and 384mg/kg/24h, then injected intraperitoneally (i.p) with 1.5 mg/kg/24h Scopolamine (Scop). Mice were tested on the Y-maze and the Morris water maze.

Results: Frequency and percentage of alternation of treatment dose 2 had much higher values than Scop (p<0.05). Glantamine (Galan) group and treatment dose 1 had higher values than the control group but not statistically significant (p>0.05). The time taken for mice to swim when finding a platform at 7th day in treatment groups 1 and 2, the Galan group, decreased differently compared to the Scop group (p<0.05). Mice receiving Hup A for 21 consecutive days with dose 2 increased their swimming time at the dock compared to the Scop group (p<0.05) and was equivalent to the control group (p>0.05).

Conclusion: Mice given Hup A soft capsules have the effect of enhancing memory by increasing the frequency of alternating turns, reducing the time it takes mice to swim to find the platform and increasing the swimming time at the platform.

References
[1]
X Ma, C Tan, D Zhu et al., Huperzine A from Google Scholar
[2]
Huperzia species--an ethnopharmacolgical Google Scholar
[3]
review. J Ethnopharmacol, 113(1): 15-34, 2007. Google Scholar
[4]
HY Zhang, New insights into huperzine A for Google Scholar
[5]
the treatment of Alzheimer’s disease. Acta Google Scholar
[6]
Pharmacol Sin, 33(9): 1170, 2012. Google Scholar
[7]
R Wang, H Yan, XC Tang, Progress in studies Google Scholar
[8]
of huperzine A, a natural cholinesterase inhibitor Google Scholar
[9]
from Chinese herbal medicine. Acta Pharmacol Google Scholar
[10]
Sin, 27(1): 1-26, 2006. Google Scholar
[11]
Y Yang, L Dai, D Wu et al., In Vitro Propagation, Google Scholar
[12]
Huperzine A Content and Antioxidant Activity Google Scholar
[13]
of Three Genotypic Huperzia serrata. Plants Google Scholar
[14]
(Basel), 10(6), 2021. Google Scholar
[15]
WJ Szypuła, B Wileńska, A Misicka et al., Google Scholar
[16]
Huperzine A and Huperzine B Production by Google Scholar
[17]
Prothallus Cultures of Huperzia selago (L.) Google Scholar
[18]
Bernh. ex Schrank et Mart. Molecules, 25(14), Google Scholar
[19]
FSA Yadang, Y Nguezeye, CW Kom et al., Google Scholar
[20]
Scopolamine-Induced Memory Impairment in Google Scholar
[21]
Mice: Neuroprotective Effects of Carissa edulis Google Scholar
[22]
(Forssk.) Valh (Apocynaceae) Aqueous Extract. Google Scholar
[23]
Int J Alzheimers Dis, 2020: 6372059. Google Scholar
[24]
Phạm Thắng, Bệnh Alzheimer và các thể sa sút Google Scholar
[25]
trí tuệ khác, Nhà xuất bản Y học, Hà Nội, 2010. Google Scholar
[26]
JF Flood, A Cherkin, Scopolamine effects on Google Scholar
[27]
memory retention in mice: a model of dementia. Google Scholar
[28]
Behav Neural Biol, 45(2): 169-84, 1986. Google Scholar
[29]
TK Dang, SM Hong, VT Dao et al., Google Scholar
[30]
Neuroprotective effects of total alkaloids fraction Google Scholar
[31]
of Huperzia serrata on scopolamine-induced Google Scholar
[32]
neurodegenerative animals. Phytother Res, Google Scholar
[33]
(1): 140-150, 2023. Google Scholar