Articles Vol. 65 No. CĐ 2 - NCKH 08/04/2024

17. CLINICAL, SUBCLINICAL CHARACTERISTICS AND RESULTS OF TREATMENT OF COVID-19 IN PREGNANT WOMEN AT THE NATIONAL HOSPITAL OF TROPICAL DISEASES

Nguyen Quang Huy1,2, Nguyen Kim Thu3,4, Tran Van Quy1,2, Nguyen Thi Thuong1,2, Vu Dinh Phu1,2
1 National Hospital Of Tropical Diseases
2 Bệnh viện Bệnh nhiệt đới Trung ương
3 Hanoi Medical University
4 Đại học Y Hà Nội
Corresponding author: nguyenquanghuy.hmu@gmail.com
DOI: 10.52163/yhc.v65iCD2.1021
16 Views
8 Downloads
Keywords
COVID-19, Pregnant women, results of treatment.
Abstract

Objective: Describe clinical features, paraclinical characteristics and treatment results of COVID-19 in pregnant women treated at the National Hospital of Tropical Diseases in 2020-2022.

Subject and method: A cross-sectional study was carried out in the medical record of 209 pregnant women with COVID-19 who were diagnosed with COVID-19 by RT-PCR-SARS-CoV-2 test, admitted to the National Hospital for Tropical Diseases from January 1, 2020 to June 30, 2022.

Results: Common symptoms of COVID-19 disease in Pregnant women are: cough (82.3%) and fever (67.5%). Abnormal subclinical features of COVID-19 in Pregnant women are: anemia (34.5%), lymphopenia (51.7%), increased D-dimer (94.7%), increased fibrinogen (59.7%), increased CRP (78%), elevated LDH (40.3%). Outcomes of pregnant women: the mortality rate was 2.9%. Pregnancy outcomes: 35.4% (74/209) of pregnant women need to terminate pregnancy, 85.1% (63/74) terminate during preterm pregnancy.

Conclusion: Common symptoms of COVID-19 in Pregnant women are cough and fever. COVID-19 disease in pregnant women has the intention of increasing D-dimer, fibrinogen, CRP, LDH and lymphopenia, decreasing hemoglobin. Pregnant women with COVID-19 have a high rate of severe illness but the death rate is not high. Pregnant women with COVID-19 tend to need early cesarean sections.

References
[1]
Coronavirus disease (COVID-19), World Health Google Scholar
[2]
Organization. Accessed May 08, 2022. https:// Google Scholar
[3]
www.who.int/health-topics/coronavirus Google Scholar
[4]
Allotey J, Stallings E, Bonet M et al., Clinical Google Scholar
[5]
manifestations, risk factors, and maternal and Google Scholar
[6]
perinatal outcomes of coronavirus disease 2019 Google Scholar
[7]
in pregnancy: living systematic review and Google Scholar
[8]
metaanalysis. 2020;370. Google Scholar
[9]
Di Mascio D, Buca D, Berghella V et al., Google Scholar
[10]
Counseling in maternal-fetal medicine: SARSCoV-2 Google Scholar
[11]
infection in pregnancy. Ultrasound in Google Scholar
[12]
obstetrics & gynecology : the official journal of the Google Scholar
[13]
International Society of Ultrasound in Obstetrics Google Scholar
[14]
and Gynecology. May 2021;57(5):687-697. Google Scholar
[15]
doi:10.1002/uog.23628 Google Scholar
[16]
Trần Danh Cường, Đặng Công Việt, Lê Chí Google Scholar
[17]
Quang và cộng sự, Đặc điểm lâm sàng, cận lâm Google Scholar
[18]
sàng thai phụ nhiễm SARS-CoV-2 tại Bệnh viện Google Scholar
[19]
Phụ sản Trung ương và Bệnh viện Nhiệt đới Trung138 Google Scholar
[20]
ương; Tạp chí Phụ sản; 10/07 2022;20(3):36-40. Google Scholar
[21]
doi:10.46755/vjog.2022.3.1437 Google Scholar
[22]
Knight M, Bunch K, Vousden N et al., Google Scholar
[23]
Characteristics and outcomes of pregnant women Google Scholar
[24]
admitted to hospital with confirmed SARSCoV-2 Google Scholar
[25]
infection in UK: national population Google Scholar
[26]
based cohort study. BMJ (Clinical research ed). Google Scholar
[27]
Jun 8 2020;369:m2107. doi:10.1136/bmj.m2107 Google Scholar
[28]
Nguyễn Thị Hồng, Nguyễn Phương Sinh, Bế Thị Google Scholar
[29]
Hoa và cộng sự, Đặc điểm lâm sàng và kết quả Google Scholar
[30]
sản khoa của sản phụ nhiễm covid 19 tại trung Google Scholar
[31]
tâm hồi sức covid thái nguyên; Tạp chí Y học Google Scholar
[32]
Việt Nam. 08/07 2023;528(2)doi:10.51298/vmj. Google Scholar
[33]
v528i2.6071 Google Scholar
[34]
Khalil A, Kalafat E, Benlioglu C et al., Google Scholar
[35]
SARS-CoV-2 infection in pregnancy: A Google Scholar
[36]
systematic review and meta-analysis of Google Scholar
[37]
clinical features and pregnancy outcomes; Google Scholar
[38]
EClinicalMedicine, 2020 Aug:25:100446. doi: Google Scholar
[39]
1016/j.eclinm.2020.100446. Epub 2020 Jul 3. Google Scholar
[40]
Oshay RR, Chen MY, Fields BK et al., Google Scholar
[41]
COVID-19 in pregnancy: a systematic review of Google Scholar
[42]
chest CT findings and associated clinical features Google Scholar
[43]
in 427 patients; Clin Imaging, 2021;75:75-82. Google Scholar
[44]
doi: 10.1016/j.clinimag.2021.01.004. Epub 2021 Google Scholar
[45]
Jan 13. Google Scholar
[46]
Péju E, Belicard F, Silva S et al., Management Google Scholar
[47]
and outcomes of pregnant women admitted to Google Scholar
[48]
intensive care unit for severe pneumonia related Google Scholar
[49]
to SARS-CoV-2 infection: the multicenter and Google Scholar
[50]
international COVIDPREG study; Intensive Google Scholar
[51]
Care Med (2022) 48:1185–1196 https://doi. Google Scholar
[52]
org/10.1007/s00134-022-06833-8 Google Scholar
[53]
Kalafat E, Prasad S, Birol P, et al. An internally Google Scholar
[54]
validated prediction model for critical Google Scholar
[55]
COVID-19 infection and intensive care unit Google Scholar
[56]
admission in symptomatic pregnant women. Google Scholar
[57]
American journal of obstetrics and gynecology. Google Scholar
[58]
Mar 2022;226(3):403.e1-403.e13. doi:10.1016/j. Google Scholar
[59]
ajog.2021.09.024 Google Scholar