MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN HIỆU QUẢ TÁI KHOÁNG HÓA CỦA CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE TRÊN MEN RĂNG KÉM KHOÁNG HÓA MEN RĂNG HÀM, RĂNG CỬA: TỔNG QUAN HỆ THỐNG
Nội dung chính của bài viết
Tóm tắt
Mục tiêu: Nghiên cứu tổng quan hệ thống này nhằm tổng hợp, phân tích một số yếu tố liên quan đến hiệu quả tái khoáng của casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) trên men răng kém khoáng hóa men răng hàm, răng cửa (MIH).
Phương pháp: Thiết kế nghiên cứu theo bảng kiểm PRISMA, thỏa mãn tiêu chí PICO trên 4 cơ sở dữ liệu: PubMed, Google Scholar, Cochrane, Embase và tìm kiếm bằng tay.
Kết quả: Lựa chọn được 18 bài báo, trong đó có 10 thử nghiệm đối chứng ngẫu nhiên, 6 nghiên cứu in vitro và 2 nghiên cứu lâm sàng không ngẫu nhiên. 3/6 nghiên cứu chỉ ra CPP-ACP và CPP-ACFP có hiệu quả tái khoáng tốt hơn trên các tổn thương trắng so với tổn thương vàng trong thời gian theo dõi ngắn. 2/6 nghiên cứu chỉ ra CPP-ACFP tái khoáng nhiều hơn trên tổn thương vàng khi theo dõi dài. 1 nghiên cứu chỉ ra CPP-ACFP có hiệu quả tái khoáng nhanh hơn CPP-ACP trên các tổn thương vàng trong giai đoạn đầu. 3 nghiên cứu chỉ ra thêm fluor vào CPP-ACP không tạo ra sự khác biệt về hiệu quả tái khoáng khi theo dõi lâu dài.
Kết luận: CPP-ACP có hiệu quả tái khoáng trên tổn thương trắng tốt hơn so với tổn thương vàng trong giai đoạn đầu. Fluor giúp tăng tốc độ tái khoáng ban đầu nhưng không có sự khác biệt đáng kể về hiệu quả lâu dài.
Chi tiết bài viết
Tài liệu tham khảo
[1] Bekes K. Molar incisor hypomineralization: a clinical guide to diagnosis and treatment. Springer, 2020. doi: 10.1007/978-3-030-31601-3.
[2] Nguyễn Quốc Hoàn. Hiệu quả điều trị các răng phía trước mắc MIH có sử dụng nhựa xâm nhập: tổng quan hệ thống. Thư viện đại học Y Hà Nội, 2024. https://thuvien.hmu.edu.vn/pages/cms/FullBookReader.aspx?Url=/pages/cms/TempDir/books/202407261444-d534e70b-5826-4735-a7a3 86a777205c0f//FullPreview&TotalPage=93&ext=jpg#page/1/mode/2up
[3] Inchingolo A.M et al. Treatment approaches to molar incisor hypomineralization: a systematic review. J Clin Med, 2023, 12 (22): 7194. doi: 10.3390/jcm12227194.
[4] Võ Trương Như Ngọc. Kém khoáng hóa men răng hàm lớn răng cửa MIH. Nhà xuất bản Giáo dục Việt Nam, 2023.
[5] Cavalcante B.G.N et al. Non-invasive strategies for remineralization and hypersensitivity management in molar-incisor hypomineralization - a systematic review and meta-analysis. J Clin Med, 2024, 13 (23): 7154. doi: 10.3390/jcm13237154.
[6] Baroni C et al. MIH supplementation strategies: prospective clinical and laboratory trial. J Dent Res, 2011, 90 (3): 371-376. doi: 10.1177/0022034510388036.
[7] Crombie F.A et al. Mineralisation of developmentally hypomineralised human enamel in vitro. Caries Res, 2013, 47 (3): 259-263. doi: 10.1159/000346134.
[8] Kumar A et al. An evaluation of remineralised MIH using CPP-ACP and fluoride varnish: an in-situ and in vitro study. Eur Arch Paediatr Dent, 2022, 23 (1): 79-87, Feb. doi: 10.1007/s40368-021-00630-5.
[9] Franco S et al. In vitro polarized Raman analysis for the evaluation of the efficacy of CPP-ACP remineralizing mousse in tooth hypomineralization. Results Chem, 2021, 3: 100232. doi: 10.1016/j.rechem.2021.100232.
[10] Cardoso-Martins I, Pessanha S et al. Evaluation of the efficacy of CPP-ACP remineralizing mousse in molar-incisor hypomineralized teeth using polarized Raman and scanning electron microscopy-an in vitro study. Biomedicines, 2022, 10 (12): 3086. doi: 10.3390/biomedicines10123086.
[11] Cardoso-Martins I, Arantes-Oliveira S et al. Evaluation of the efficacy of CPP-ACP remineralizing mousse in MIH white and yellow opacities-in vitro vickers microhardness analysis. Dent J, 2022, 10 (10): 186. doi: 10.3390/dj10100186.
[12] Ozgül B.M et al. Clinical evaluation of desensitizing treatment for incisor teeth affected by molar-incisor hypomineralization. J Clin Pediatr Dent, 2013, 38 (2): 101-105.
[13] Bakkal M et al. The effect of casein phosphopeptide-amorphous calcium phosphate on molar-incisor hypomineralisation: a pilot study. Oral Health Prev Dent, 2017, 15 (2): 163-167. doi: 10.3290/j.ohpd.a37928.
[14] Biondi A.M et al. Comparison of mineral density in molar incisor hypomineralization applying fluoride varnishes and casein phosphopeptide-amorphous calcium phosphate. Acta Odontol Latinoam, 2017, 30 (3): 118-123.
[15] Pasini M et al. Molar incisor hypomineralization treatment with casein phosphopeptide and amorphous calcium phosphate in children. Minerva Stomatol, 2018, 67 (1): 20-25. doi: 10.23736/S0026-4970.17.04086-9.
[16] Bhandari R et al. In vivo comparative evaluation of esthetics after microabrasion and microabrasion followed by casein phosphopeptide-amorphous calcium fluoride phosphate on molar incisor hypomineralization-affected incisors. Contemp Clin Dent, 2019, 10 (1): 9-15, doi: 10.4103/ccd.ccd_852_17.
[17] Olgen I.C et al. Effects of different remineralization agents on MIH defects: a randomized clinical study. Clin Oral Investig, 2022, 26 (3): 3227-3238. doi: 10.1007/s00784-021-04305-9.
[18] Singh S.K. A comparative evaluation of CPP-ACP cream and fluoride varnish in remineralization of MIH-affected teeth using laser fluorescence. J South Asian Assoc Pediatr Dent, 2021, 4 (2): 117-121. doi: 10.5005/jp-journals-10077-3081.
[19] Prathima G.S et al. Effects of Xylitol and CPP-ACP chewing gum on salivary properties of children with molar incisor hypomineralization. Int J Clin Pediatr Dent, 2021, 14 (3): 412-415. doi: 10.5005/jp-journals-10005-1779.
[20] Sezer B, Tuğcu N et al. Effect of casein phosphopeptide amorphous calcium fluoride phosphate and calcium glycerophosphate on incisors with molar-incisor hypomineralization: a cross-over, randomized clinical trial. Biomed Mater Eng, 2022, 33, (4): 325-335. doi: 10.3233/BME-211371.
[21] Sezer B, Kargul B. Effect of remineralization agents on molar-incisor hypomineralization-affected incisors: a randomized controlled clinical trial. J Clin Pediatr Dent, 2022, 46 (3): 192-198, doi: 10.17796/1053-4625-46.3.4.
[22] Bardellini E et al. Molar incisor hypomineralization: optimizing treatment protocols for hypersensitivity: a randomized clinical trial. Dent J (Basel), 2024, 12, (6): 186. doi: 10.3390/dj12060186.
[23] Al-Nerabieah Z et al. Preventive efficacy of 38% silver diamine fluoride and CPP-ACP fluoride varnish on molars affected by molar incisor hypomineralization in children: a randomized controlled trial. F1000 Research, 2024, 12: 1052. doi: 10.12688/f1000research.136653.2.
[2] Nguyễn Quốc Hoàn. Hiệu quả điều trị các răng phía trước mắc MIH có sử dụng nhựa xâm nhập: tổng quan hệ thống. Thư viện đại học Y Hà Nội, 2024. https://thuvien.hmu.edu.vn/pages/cms/FullBookReader.aspx?Url=/pages/cms/TempDir/books/202407261444-d534e70b-5826-4735-a7a3 86a777205c0f//FullPreview&TotalPage=93&ext=jpg#page/1/mode/2up
[3] Inchingolo A.M et al. Treatment approaches to molar incisor hypomineralization: a systematic review. J Clin Med, 2023, 12 (22): 7194. doi: 10.3390/jcm12227194.
[4] Võ Trương Như Ngọc. Kém khoáng hóa men răng hàm lớn răng cửa MIH. Nhà xuất bản Giáo dục Việt Nam, 2023.
[5] Cavalcante B.G.N et al. Non-invasive strategies for remineralization and hypersensitivity management in molar-incisor hypomineralization - a systematic review and meta-analysis. J Clin Med, 2024, 13 (23): 7154. doi: 10.3390/jcm13237154.
[6] Baroni C et al. MIH supplementation strategies: prospective clinical and laboratory trial. J Dent Res, 2011, 90 (3): 371-376. doi: 10.1177/0022034510388036.
[7] Crombie F.A et al. Mineralisation of developmentally hypomineralised human enamel in vitro. Caries Res, 2013, 47 (3): 259-263. doi: 10.1159/000346134.
[8] Kumar A et al. An evaluation of remineralised MIH using CPP-ACP and fluoride varnish: an in-situ and in vitro study. Eur Arch Paediatr Dent, 2022, 23 (1): 79-87, Feb. doi: 10.1007/s40368-021-00630-5.
[9] Franco S et al. In vitro polarized Raman analysis for the evaluation of the efficacy of CPP-ACP remineralizing mousse in tooth hypomineralization. Results Chem, 2021, 3: 100232. doi: 10.1016/j.rechem.2021.100232.
[10] Cardoso-Martins I, Pessanha S et al. Evaluation of the efficacy of CPP-ACP remineralizing mousse in molar-incisor hypomineralized teeth using polarized Raman and scanning electron microscopy-an in vitro study. Biomedicines, 2022, 10 (12): 3086. doi: 10.3390/biomedicines10123086.
[11] Cardoso-Martins I, Arantes-Oliveira S et al. Evaluation of the efficacy of CPP-ACP remineralizing mousse in MIH white and yellow opacities-in vitro vickers microhardness analysis. Dent J, 2022, 10 (10): 186. doi: 10.3390/dj10100186.
[12] Ozgül B.M et al. Clinical evaluation of desensitizing treatment for incisor teeth affected by molar-incisor hypomineralization. J Clin Pediatr Dent, 2013, 38 (2): 101-105.
[13] Bakkal M et al. The effect of casein phosphopeptide-amorphous calcium phosphate on molar-incisor hypomineralisation: a pilot study. Oral Health Prev Dent, 2017, 15 (2): 163-167. doi: 10.3290/j.ohpd.a37928.
[14] Biondi A.M et al. Comparison of mineral density in molar incisor hypomineralization applying fluoride varnishes and casein phosphopeptide-amorphous calcium phosphate. Acta Odontol Latinoam, 2017, 30 (3): 118-123.
[15] Pasini M et al. Molar incisor hypomineralization treatment with casein phosphopeptide and amorphous calcium phosphate in children. Minerva Stomatol, 2018, 67 (1): 20-25. doi: 10.23736/S0026-4970.17.04086-9.
[16] Bhandari R et al. In vivo comparative evaluation of esthetics after microabrasion and microabrasion followed by casein phosphopeptide-amorphous calcium fluoride phosphate on molar incisor hypomineralization-affected incisors. Contemp Clin Dent, 2019, 10 (1): 9-15, doi: 10.4103/ccd.ccd_852_17.
[17] Olgen I.C et al. Effects of different remineralization agents on MIH defects: a randomized clinical study. Clin Oral Investig, 2022, 26 (3): 3227-3238. doi: 10.1007/s00784-021-04305-9.
[18] Singh S.K. A comparative evaluation of CPP-ACP cream and fluoride varnish in remineralization of MIH-affected teeth using laser fluorescence. J South Asian Assoc Pediatr Dent, 2021, 4 (2): 117-121. doi: 10.5005/jp-journals-10077-3081.
[19] Prathima G.S et al. Effects of Xylitol and CPP-ACP chewing gum on salivary properties of children with molar incisor hypomineralization. Int J Clin Pediatr Dent, 2021, 14 (3): 412-415. doi: 10.5005/jp-journals-10005-1779.
[20] Sezer B, Tuğcu N et al. Effect of casein phosphopeptide amorphous calcium fluoride phosphate and calcium glycerophosphate on incisors with molar-incisor hypomineralization: a cross-over, randomized clinical trial. Biomed Mater Eng, 2022, 33, (4): 325-335. doi: 10.3233/BME-211371.
[21] Sezer B, Kargul B. Effect of remineralization agents on molar-incisor hypomineralization-affected incisors: a randomized controlled clinical trial. J Clin Pediatr Dent, 2022, 46 (3): 192-198, doi: 10.17796/1053-4625-46.3.4.
[22] Bardellini E et al. Molar incisor hypomineralization: optimizing treatment protocols for hypersensitivity: a randomized clinical trial. Dent J (Basel), 2024, 12, (6): 186. doi: 10.3390/dj12060186.
[23] Al-Nerabieah Z et al. Preventive efficacy of 38% silver diamine fluoride and CPP-ACP fluoride varnish on molars affected by molar incisor hypomineralization in children: a randomized controlled trial. F1000 Research, 2024, 12: 1052. doi: 10.12688/f1000research.136653.2.