12. CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF DIFFERENTIATED THYROID CARCINOMA AT MILITARY HOSPITAL 175

Le Minh Phong1, Nguyen Thanh Chung2
1 Military Hospital 175
2 Le Huu Trac National Burn Hospital

Nội dung chính của bài viết

Tóm tắt

Objective: To describe the clinical and histopathological characteristics of differentiated thyroid cancer at Military Hospital 175.


Subjects and Methods: A descriptive cross-sectional study combined with a prospective design was conducted on 42 patients diagnosed with differentiated thyroid cancer at Military Hospital 175 from July 2022 to January 2024.


Results: The mean age of patients was 45.8 ± 9.6 years, with a predominance of females (71.4%). Papillary carcinoma accounted for the majority of histopathological types (90.5%), with capsular invasion in 11.9% and invasion of adjacent organs in 4.8% of cases. The disease stages were predominantly T1 and T2 (64.3%), with no lymph node metastasis (76.2%) and no distant metastasis (97.6%). There were significant associations between age, gender, tumor size, and the status of lymph node metastasis and capsular invasion (p<0.05). Within one year post-surgery, the recurrence-free rate was 92.9%, with local recurrence at 4.7% and distant recurrence at 2.4%.


Conclusion: Differentiated thyroid cancer has a favorable prognosis with a high one-year recurrence-free rate. However, risk factors such as tumor size and invasion status should be carefully considered in diagnosis and treatment.

Chi tiết bài viết

Tài liệu tham khảo

[1] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209–49.
[2] Lim, H., et al. Trends in thyroid cancer incidence and mortality in the United States, 1974-2013. JAMA. 2017;317(13):1338–48.
[3] Cabanillas, M. E., et al. Differentiated thyroid cancer: Clinical features and treatment. Endocrinology and Metabolism Clinics of North America. 2016;45(2):317–30.
[4] Haugen, B. R., et al. American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 26(1):1–133.
[5] Nguyễn Ngọc Thắng và cộng sự. Đánh giá kết quả điều trị ung thư tuyến giáp thể biệt hóa đã phẫu thuật giai đoạn di căn bằng I-131 tại Bệnh viện Ung bướu Nghệ An. Tạp chí Y học Viện Nam. 2022;521(1):328–31.
[6] Moslehin, H. I., et al. Differentiated thyroid cancer in Iran - initial observations, histological features, management of the disease, and tumor recurrence: A review of 1689 cases. Indian J Cancer. 2016;53(2):261–4.
[7] Cakir AD, Bucak FT, Tarcin G, Turan H, Ozcan R, Evliyaoglu O, et al. Differentiated Thyroid Cancer in Children and Adolescents: Clinicopathological Characteristics of 32 Patients Followed up in our Pediatric Endocrinology Unit. Sisli Etfal Hastan Tip Bul. 2023 Jun 20;57(2):224–31.
[8] Department of Pathology, College of Medicine, AL-Iraqia University, Baghdad, Iraq, Mohsin HI, Mohammed MJ, Department of Pathology, College of Medicine, AL-Iraqia University, Baghdad, Iraq, Ahmed BS, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq, et al. View on various clinical determinants of thyroid neoplasms based on their histopathological patterns. Ro Med J. 2024 Dec 31;71(4):354–8.